urine OFF has been awarded USDA BioPreferred® designation as a USDA Certified Biobased Product. urine OFF is a revolutionary biotechnology product that eliminates urine odor and stains at the source, permanently. urine OFF uses a combination of naturally occurring micro-organisms and their enzymes to digest the uric acid crystals (which produce urine's pungent aroma) as well as urea (the sticky substance in urine) and proteins (which promote pathogen growth).